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Note High-end computer hardware, software, and are readily available Status of pharmaceutical rms within the EU is evolving Differences exist in EU member countries Highly skilled workforce, but many scientists move abroad Especially strong in basic research Europeans have mixed attitudes toward different biotech activities Approximately 20 percent of all research and development in Europe Support varies by country Modest investment in basic research and applied medical research Modest investment from nonpro ts Investment has fallen precipitously VC investment has remained strong, especially in late-stage companies Smaller companies are consolidating to survive Aggressively playing catch-up with the United States Resistance to genetically modi ed agriculture Little publicly available information on military biotech Active in sequencing and genomics research and development Numerous centers of excellence involved in research and development Modest activity in biomaterials

r J8' dS' [~g(r,r') x (n' x H(r')]

The integral in (6.1.25) is singular at r = r'. To handle this problem, we perform similarly to the Neumann case of 4, Section 1.5. Let

r = p + On (6.1.26) where p is a point on the rough surface. If 0> 0, r = r +, and if 0 < 0, r = r_. Thus, r + is infinitesimally above the surface while r _ is infinitesimally below

the surface. In (6.1.25) and (6.1.26)

IDisposable interface implementation, de ning two Dispose methods The rst part of the generated code provides a Dispose method that you

Xn'XH(r')]

(6.1.27) The f8' integration is divided into a circular disk Sa of small radius a about p and the rest which is known as the principal value integral

1 1 +1

dS' =

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though in some measures, such as the number of Internet hosts per thou sand inhabitants, Europe ranks behind the United States and Oceania However, the information technology infrastructures in the biotech centers such as United Kingdom, France, Germany, and Switzerland are among the best in the world For example, in the area of clinical data capture and analysis, the hospital information systems in Germany are unparalleled Many innovations not available in the United States, such as providing cit izens with personal smart cards containing their medical records, allow highly accurate tracking of medications, diagnoses, and treatment In con trast, perhaps 5 percent of hospitals in the United States are fully comput erized, and advanced technologies, such as smart cards, haven t been embraced by the medical community The legal-regulatory environment within Europe and the evolving Eu ropean Union is mixed.

dS' =

can customize to your requirements:

(6.1.28)

x 71' x H(r') x (71XH(r))]

(6.1.29)

where {) > 0 for r = r + and {) < 0 for r = r _. Let (p', ') be the polar coordinates of r' of circular disk of radius a centered about p

' IDisposable Protected Overridable Sub Dispose(ByVal disposing As Boolean) If Not MedisposedValue Then If disposing Then ' TODO: free unmanaged resources when explicitly called End If

dp' p'

1 1 1 1

dp' p'

Resolving the debate over the labeling of geneti cally modi ed foods and similar issues is challenging within a single country, much less achieving consensus among members of the European Union However, the drug approval process in Europe is relatively stream lined, compared with the arduous, lengthy process in the United States The shorter drug development cycle is an advantage to the companies serv ing the European market However, because the streamlined European guidelines may not satisfy the US FDA guidelines, drugs cleared for Euro pean consumption may be barred from the lucrative US market According to the EFPIA, which has a take in maximizing pro ts for its membership organizations, the EU pharmaceutical regulations are hamper ing innovation because they permit parallel trade in medicines between EU countries They also permit some nations in the Union to impose price cuts unilaterally.

d ' [-

5

d ' [_ (71{) - (p' cos ' X + p' sin ' fJ) ] 411"(p,2 + {)2)3/2

dS''V (- -')

=-n"2

d ' ,

The disposedValue variable keeps track of whether the object has already been disposed so that it won t dispose it again The parameter passed to this customizable Dispose method de nes whether Dispose is called from the IDisposable interface Dispose method (shown next) If so, the code should free any unmanaged resources, so put your cleanup code here, by the rst TODO Task List comment If you have shared resources (those de ned without a speci c instance), put that cleanup code by the second TODO Task List comment When all the unmanaged resources are freed, this code sets the disposedValue property so that it won t dispose again The second part of the generated code de nes the implemented interface:

PP(p,2+{)2)3/2

= -71"2 - (p,2 + {)2)1/2

- (a2 + {)2)1/2 1

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